Building is related to the city in every respect. They are a natural response to the accumulation of population and cost of land. Building will be resulted to justify his answer to the concept of the design and building results. Buildings in the city in terms of resistance and stability need to take advantage of structural systems are appropriate. Steel sheer wall system is interesting to researchers for the good performance in absorbing lateral forces such as earthquakes and for this reason used in normal and high-rise buildings in earthquake-prone countries is used. In few cases, it is unavoidable to make openings because of applying architecture and beautification’s needs and also nonstructural considerations like position and path of installation systems. Requirements openings in Steel shear wall system like all structural systems are necessary to the terms of architecture and design considerations. In these cases openings must be large enough in size and number so they can be used in the cases cited. The creation of such large openings could severely change the stress distribution within the wall and often the failure mode affects the behavior of the wall loaded. The main question of this article is the causes off multiple openings and the behavior of steel shear wall system with multiple openings. In this article the effect of the position and arrangement of multiple openings on the behavior of this type of wall has been studied in terms of performance by using nonlinear dynamic analysis. For this purpose a set of seven earthquake ground motions were appropriately selected and applied to the systems and the results were analyzed.