The aim of the present study was to explore the relationship between media literacy and social skills among citizens in Isfahan. To this end, a descriptive-correlation methodology was employed. The population under study consisted of all citizens living in Isfahan who were reported to be 1796967 persons in 2013. Using Cochran formula, 384 persons were selected by stratified sampling and were included in the research sample. The instruments used in the study were Karaman’s and Karatash’s (2009) Standard Media Literacy Questionnaire and Standard Social Skills Questionnaire (Oldmeadow et al., 2013). The validity of the questionnaires was confirmed using content validity and factor analysis. The reliability values of Media Literacy Questionnaire and Social Skills Questionnaire were determined by Cronbach’s alpha coefficient and were reported as 0.876 and 0.896, respectively. The results of the study indicated that media literacy with an influence rate of 0.39 affects social skills. Besides, media knowledge (critical thinking) as a component of media literary with an influence rate of 0.37 affects social skills. It was also found that analysis and reaction as a component of media literary with an influence rate of 0.68 affects social skills. The same was the case with judgment and observation of hidden messages as a component of media literary which affects social skills with an influence rate of 0.53. Media literacy with an influence rate of 0.33 was found to affect the expression social skill feelings. Finally, based on the findings of the study concerning the relationship between research variables, some suggestions were offered to improve media literary and social skills of people living in Isfahan.