This research aims to study the role and function of economic-social nongovernmental organizations' frontier cooperatives in sustainable development with emphasize on developing cooperatives in frontier regions. In this research study the position, function and performance of cooperatives of four frontier cities including Agh Gola city, Gaz port city, Turkman port city and kelaleh were selected, studied and analyzed. The method of study was descriptive-analytical and data documental collection was analyzed in three dimensions of sustainable development including economic, social and environmental by using econometrics (OLS). The results of data analyses have showed that the activities of nongovernmental organizations such as frontier cooperatives of these regions leave the most effects respectively in the field of social,� economic� and� environmental� indicators.� In� the� other� word,� through� development� in frontier cooperatives and expansion of their activities in borders, at first they had the most positive effect in development of social indicators and at the second degree , they had effect on economic and environmental indicators and dimensions and the relationship between frontier cooperatives' innate duties and their further development with sustainable development of border and central regions is always significant and some strategic programs must be planned in these fields and its relative dimensions.